Functional Brain Receptor Imaging with Positron Emission Tomography

Authors

  • Simon M. Ametamey
  • Gerrit Westera
  • Pascale Gucker
  • Roland Schönbächler
  • Michael Honer
  • Jörg E. Spang
  • P. August Schubiger

DOI:

https://doi.org/10.2533/chimia.2000.622

Keywords:

Dopamine and serotonin transporters, Ecstasy, Epibatidine, Pet, Pharmaceutical chemistry

Abstract

A new cocaine derivative for imaging the dopamine transporter has been developed. Measurements of radioligand binding of 11C-(+)-McN-5652 in vivo with PET suggests that ecstasy interacts directly with the serotonin reuptake sites and that a single oral dose of ecstasy (1.5 mg/kg) does not cause any changes in the serotonin transporter density in the human brain. Finally, a number of epibatidine derivatives have been developed as ligands to study the central nAChRs in vivo, however, toxicity studies prevented further clinical use.

Downloads

Published

2000-11-29

How to Cite

[1]
S. M. Ametamey, G. Westera, P. Gucker, R. Schönbächler, M. Honer, J. E. Spang, P. A. Schubiger, Chimia 2000, 54, 622, DOI: 10.2533/chimia.2000.622.

Issue

Section

Scientific Articles