Spirodiclofen and Spiromesifen – Novel Acaricidal and Insecticidal Tetronic Acid Derivatives with a New Mode of Action

Authors

  • Thomas Bretschneider
  • Jordi Benet-Buchholz
  • Reiner Fischer
  • Ralf Nauen

DOI:

https://doi.org/10.2533/000942903777678588

Keywords:

Acaricide, Insecticide, Spirodiclofen, Spiromesifen, Tetronic acid

Abstract

The broad spectrum acaricides spirodiclofen (BAJ2740, trade name: Envidor®) and spiromesifen (BSN2060, trade name: Oberon®) with an additional excellent activity against whiteflies, both belong to the new chemical class of tetronic acid derivatives discovered at Bayer CropScience during the 1990s. The discovery process starting from herbicidal PPO (protoporphyrinogen oxidase) chemistry, the synthetic routes leading to the products, and some insight into process development of central intermediates is given. Spirodiclofen and spiromesifen have a new mode of action (interference with lipid biosynthesis), show no cross-resistance to any resistant mite or whitefly field population and are therefore valuable tools for resistance management.

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Published

2003-11-01

How to Cite

[1]
T. Bretschneider, J. Benet-Buchholz, R. Fischer, R. Nauen, Chimia 2003, 57, 697, DOI: 10.2533/000942903777678588.

Issue

Section

Scientific Articles