Tuning Molecular Recognition of RNA and DNA via Sugar Modification
Keywords:Antisense, Dna recognition, Dna triple-helix, Molecular beacons, Pyrrolidino nucleosides
AbstractThis minireview highlights three aspects of our recent work in the area of sugar modified oligonucleotide analogues. It provides an overview over recent results on the conformationally constrained analogue tricyclo-DNA with special emphasis of its antisense properties, it summarizes results on triple-helix forming oligodeoxynucleotides containing pyrrolidino-nucleosides with respect to DNA recognition via the dual recognition mode, and it highlights the advantageous application of the orthogonal oligonucleotidic pairing system homo-DNA in molecular beacons for DNA diagnostics.
How to Cite
C. J. Leumann, Chimia 2005, 59, 776, DOI: 10.2533/000942905777675624.
Copyright (c) 2005 Swiss Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.