Preparation of Modified RNA Sequences for Biological Research
Keywords:Ligation, Nucleic acids, Organic synthesis, Phosphoramidites, Rna
AbstractOur group is working on the development of reliable access to biologically relevant, long, and modified RNA sequences. Here, we briefly present the chemical synthesis of such sequences with 2?-O-triisopropylsilyloxymethyl (= 2?-O-tom) protected ribonucleoside phosphoramidites, their template-directed enzymatic ligation, and some examples of modified nucleotides, designed to promote structural and biological studies.
How to Cite
S. Pitsch, P. Wenter, A. Stutz, L. Reymond, S. Porcher, A. Peer, E. Muller, M. Meyyappan, F. Meylan, C. Denarie, D. Ackermann, X. Wu, Chimia 2005, 59, 808, DOI: 10.2533/000942905777675633.
Copyright (c) 2005 Swiss Chemical Society
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