An Asymmetric Synthesis of PPAR-? Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate

Authors

  • John R. Rizzo
  • Tony Y. Zhang

DOI:

https://doi.org/10.2533/chimia.2006.580

Keywords:

Asymmetric synthesis, Navaglitazar, Noninsulin dependent diabetes mellitus (niddm), Peroxisome proliferator activated receptor (ppar) gamma agonist

Abstract

An asymmetric synthesis of navaglitazar, a peroxisome proliferator activated receptor (PPAR) ? agonist, from commercially available (+)-methyl (2S,3R)-3-(4-methoxyphenyl)glycidate, is described. The new synthesis features high overall yield, low solvent usage, crystalline intermediates and operational simplicity.

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Published

2006-09-01

How to Cite

[1]
J. R. Rizzo, T. Y. Zhang, Chimia 2006, 60, 580, DOI: 10.2533/chimia.2006.580.

Issue

Vol. 60 No. 9 (2006): Process Chemistry

Section

Scientific Articles

License

Copyright (c) 2006 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.