New Practical Synthesis of the Exceptional Musk Odorants (R)-Muscone and (R,Z)-5-Muscenone
Keywords:Aldol reaction, Amino alcohol, Asymmetric synthesis, Dynamic kinetic resolution, Elimination
AbstractHerein we describe a short and practical synthesis of the exceptional musk odorants (R)-muscone and (R,Z)-5-muscenone from a readily available achiral macrocyclic diketone. The key step of the synthesis is the first sodium N-methylephedrate mediated enantioselective aldol condensation reaction (up to 76% ee). This new type of reaction proceeds via a dynamic kinetic resolution of an aldol intermediate.
How to Cite
O. Knopff, J. Kuhne, Chimia 2008, 62, 489, DOI: 10.2533/chimia.2008.489.
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