Nickamine: A General Catalyst for Cross Coupling of Alkyl Halides and Direct Alkylation

Authors

  • Xile Hu Werner Prize winner 2011, Ecole Polytechnique Fédérale de Lausanne Institute of Chemical Sciences and Engineering EPFL-ISIC-LSCI CH-1015 Lausanne, Switzerland. xile.hu@epfl.ch

DOI:

https://doi.org/10.2533/chimia.2012.154

Keywords:

C–h functionalization, Cross coupling, Homogeneous catalysis, Organometallic chemistry, Nickel

Abstract

A nickel pincer complex, Nickamine, is shown to be an active catalyst for a large number of reactions including cross coupling of non-activated alkyl halides and direct C–H alkylation of alkynes and aromatic heterocycles. This work was rewarded by the 2011 Werner Prize from the Swiss Chemical Society.

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Published

2012-04-25