Molecular Design of Synthetic Benzimidazoles for the Switchover of the Duplex to G-quadruplex DNA Recognition

Authors

  • Basudeb Maji Department of Organic Chemistry Indian Institute of Science Bangalore 560012, India
  • Santanu Bhattacharya Department of Organic Chemistry Indian Institute of Science Bangalore 560012, India; Chemical Biology Unit Jawaharlal Nehru Centre for Advanced Scientific Research Bangalore 560012, India; J.C. Bose Fellow, Department of Science and Technology New Delhi, India. sb@orgchem.iisc.ernet.in

DOI:

https://doi.org/10.2533/chimia.2013.39

Keywords:

Anti-cancer, Benzimidazole, Cytotoxicity, Dna, G-quadruplex, Telomerase, Trap-lig assay

Abstract

Benzimidazole derivatives are well known for their antibacterial, antiviral, anticonvulsant, antihistaminic, anthelmintic and antidepressant activities. Benzimidazole's unique base-selective DNA recognition property has been studied widely. However, most of the early benzimidazole systems have been targeted towards the binding of duplex DNA. Here we have shown the evolution and progress of the design and synthesis of new benzimidazole systems towards selective recognition of the double-stranded DNA first. Then in order to achieve selective recognition of the G-quadruplex DNA and utilize their potential as future anti-cancer drug candidates, we have demonstrated their selective cytotoxicity towards the cancer cells and potent telomerase inhibition ability.

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Published

2013-02-27

How to Cite

[1]
B. Maji, S. Bhattacharya, Chimia 2013, 67, 39, DOI: 10.2533/chimia.2013.39.