Environmental Metrics to Drive a Cultural Change: Our Green Eco-Label

Authors

  • Ulrich Onken Novartis Chemical and Analytical Development, CH-4002 Basel
  • Agnieszka Koettgen Novartis Chemical and Analytical Development, CH-4002 Basel
  • Holger Scheidat Novartis Chemical and Analytical Development, CH-4002 Basel
  • Patrick Schueepp Novartis Chemical and Analytical Development, CH-4002 Basel
  • Fabrice Gallou Novartis Chemical and Analytical Development, CH-4002 Basel;, Email: fabrice.gallou@novartis.com

DOI:

https://doi.org/10.2533/chimia.2019.730

PMID:

31514774

Keywords:

Green chemistry, Metrics, Sustainability

Abstract

A novel Green Chemistry Process Scorecard was developed to assess the environmental impact of chemical production processes to manufacture the Active Pharmaceutical Ingredients (API) within our portfolio. These new metrics not only cover the resource consumption from the overall chemical synthesis, but also consider the use of Substances of Concern and the number of chemical transformations. The Process Mass Intensity (PMI), i.e. the ratio of accumulated kilogram quantities of materials per kilogram of API, is used to quantify the resource consumption. An 'eco-label' for specific APIs is used to visualize the environmental impact from their chemical synthesis. For an overview of the environmental impact of a complete product portfolio, a diagram of PMI or total waste quantity vs. the number of synthetic steps can also be used as a visualization tool to identify chemical syntheses with a high need for process improvements. Implementation of this process led to a dramatic change of mindset within the organization. It now supports and drives the decision making at Chemical and Analytical Development, and helps to trigger new projects more readily for sustainability reasons.

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Published

2019-09-18

How to Cite

[1]
U. Onken, A. Koettgen, H. Scheidat, P. Schueepp, F. Gallou, Chimia 2019, 73, 730, DOI: 10.2533/chimia.2019.730.