Cascades, Catalysis and Chiral Ligand Control with SmI₂; The Rebirth of a Reagent

Áron Péter; David J. Procter

doi:10.2533/chimia.2020.18

Cascades, Catalysis and Chiral Ligand Control with SmI₂; The Rebirth of a Reagent

Authors

Áron Péter Department of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK
David J. Procter Department of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK;, Email: david.j.procter@manchester.ac.uk

DOI:

https://doi.org/10.2533/chimia.2020.18

PMID:

32200782

Keywords:

Enantioselective desymmetrisation, Radical cascade, Radical relay catalysis, Samarium diiodide

Abstract

This review focuses on recent developments from our laboratory in the field of radical reactions mediated by the archetypal reductive single electron transfer (SET) reagent, SmI₂. Namely, we have expanded the scope of reducible carbonyl moieties to esters and amides and have exploited the resultant ketyl radicals in radical cascade reactions that generate unprecedented scaffolds. Moreover, we have taken the first steps to address the long-standing challenges of catalysis and chiral ligand control associated with the reagent.