Optical Control of Glycerolipids and Sphingolipids

Authors

  • Dirk Trauner Dept. Chemistry, NYU, NYC, NY 10003
  • Johannes Morstein Dept. Cell. And Mol. Pharmacoloy, UCSF, SF, CA 94158

DOI:

https://doi.org/10.2533/chimia.2021.1022

Keywords:

Photopharmacology, Photoswitches, Glycerolipids, sphingolipids

Abstract

Glycerolipids, Sphingolipids, and Sterols are the three major classes of membrane lipids. Both glycerolipids and sphingolipids are comprised of combinations of polar headgroups and fatty acid tails. The fatty acid tail can be chemically modified with an azobenzene photoswitch giving rise to photoswitchable lipids. This approach has yielded a number of photopharmacological tools that allow to control various aspects of lipid assembly, metabolism, and physiology with light.

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Published

2021-12-09

How to Cite

[1]
D. Trauner, J. Morstein, Chimia 2021, 75, 1022, DOI: 10.2533/chimia.2021.1022.