Targeting Ion Channel TRPM4

Authors

DOI:

https://doi.org/10.2533/chimia.2022.1039

Keywords:

Cancer, Cardiac disease, TRPM4, Small-molecule inhibitors

Abstract

The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecules that block TRPM4 in the low µM range. Furthermore, we investigated the pathophysiology of TRPM4 in cardiac conditions, immune diseases and cancer using these novel inhibitors, molecular biology techniques and functional assays.

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Published

2022-12-21

How to Cite

[1]
B. Preti, J.-S. Rougier, I. Papapostolou, F. Bochen, C. E. Gerber, H. Abriel, M. Lochner, C. Peinelt, Chimia 2022, 76, 1039, DOI: 10.2533/chimia.2022.1039.