TY - JOUR AU - Biner, Olivier AU - Schick, Thomas AU - Ganguin, Aymar Abel AU - von Ballmoos, Christoph PY - 2018/05/30 Y2 - 2024/03/28 TI - Towards a Synthetic Mitochondrion JF - CHIMIA JA - Chimia VL - 72 IS - 5 SE - Scientific Articles DO - 10.2533/chimia.2018.291 UR - https://www.chimia.ch/chimia/article/view/2018_291 SP - 291 AB - Our group at the University of Bern uses biochemical and biophysical techniques to unravel details of the molecular mechanism of membrane proteins. Of special interest are the large multi-subunit complexes of the universally conserved respiratory chain and the ATP synthase that are found in mitochondria and aerobic bacteria. In a bottom-up approach using purified membrane proteins and synthetic lipids, we aim to mimic the basic processes of oxidative phosphorylation. We further develop methodologies to increase the complexity of such artificial systems, paving the way for a synthetic mitochondrion. In this minireview, we summarize recent efforts of our groups and others towards a synthetic respiratory chain. ER -