TY - JOUR AU - Müller, Hans-Martin AU - Dobler, Max AU - Zbinden, Peter AU - Seebach, Dieter PY - 1991/12/18 Y2 - 2024/03/29 TI - Bildung 12- bis 40-gliedriger Oligolide aus enantiomerenreinen 3-Hydroxybuttersäure-Derivaten – Bausteine für eine 2₁- und eine 3₁-Helix JF - CHIMIA JA - Chimia VL - 45 IS - 12 SE - Forschung DO - 10.2533/chimia.1991.376 UR - https://www.chimia.ch/chimia/article/view/1991_376 SP - 376 AB - <p>Trimeric, tetrameric, and pentameric oligolides are formed preferentially from (S)-βbutyrolactone, or from methyl (R)-3-hydroxybutanoate, upon prolonged treatment with catalytic amounts of tetraoxadistannacyclodecane (Shanzer's macrolactonization catalyst) in refluxing xylene. The crystal structure of the tetramer is described. Substructures of the larger folded oligolides are used for the construction of a left-handed 2<sub>1</sub>-helix, as found in the biopolymer PHB, and a heretofore unknown right-handed 3<sub>1</sub>-helix.</p> ER -